The Great Plains Regional office is responsible for the direction and oversight of Bureau responsibilities and activities in South Dakota, North Dakota, and Nebraska. The Office of the Regional Director provides program direction and supervision to 12 Agencies encompassing 16 federally recognized Tribes. Programs includes: tribal government, enrollment, claims, self-determination, housing improvement program, loan guaranty and interest subsidy program, land titles and records office, probate and estate services, real estate services, Indian land consolidation program, Division of Natural Resources, Human services (which includes general assistance, burial assistance, disaster assistance, emergency assistance, adult care assistance, and child assistance), Tribal transportation program, road maintenance, and Division of Environment, Safety, and Cultural Resources Managements.

Responsible for protecting and serving the citizens of Deadwood. Community Service Officers are responsible for enforcement of various issues such as snow/ice removal.