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Located on the Pine Ridge Reservation, it is an ambulatory care center with outpatient services. Services include primary care, pediatric, women's health, optometry, dental, behavioral health, podiatry, radiology, and laboratory tests.

Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, the Browns Valley Clinic in Browns Valley, Minnesota, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), and Women's Health. The take-back site is available.

Offering multi-specialty health care services such as 3D mammography, family medicine, lab, x-ray, and ultrasound services, obstetrics and gynecology (OBGYN), pediatrics, physical therapy, sexual health and intimacy care, and women's health services. Also offers behavioral health services such as dialectical behavioral therapy (DBT) and eye movement desensitization and reprocessing (EMDR) therapy.

A full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Bison Clinic is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

A family practice and women's health clinic offering comprehensive care to newborns, pediatrics, adult, and geriatric patients. Services include preventative care, annual examinations, Department of Transportation (DOT) examinations, immunizations, obstetrical care, women's health care, mental/behavioral health services, radiology, and lab services.

Monument Health Spearfish Hospital offers extensive patient services centralized at one location which includes both the hospital and Spearfish Monument Medical Clinic. Services include emergency care: 24 hours a day / 7 days a week, diabetes care, heart & vascular care, home care, hospice, labor & delivery, laboratory services, medical imaging, physical therapy & rehabilitation, surgery, swing-bed program, telemedicine, and serves as a medication disposal site.

Featured health services include cancer care, blood diseases and disorders, brain and spine care, dentistry, emergency and trauma, heart and vascular care, infectious disease and public health, laboratory, nutrition, pain management, pregnancy and birth, Radiology and imaging, respiratory and pulmonary care, sleep medicine, surgery, telemedicine, therapy and rehabilitation, wellness and preventive care, women's health, and wound care.

Horizon Health - Fort Thompson is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Walk-in appointments welcome.

Providing family medicine (including flu shots).

Featured health services include cancer care, brain and spine care, children's health, dermatology, ear, nose, and throat, laboratory, orthopedics, therapy and rehabilitation, podiatry, pregnancy and birth, primary care, radiology and imaging, urgent care, urology, women's health, and cardiology.

Horizon Health - Yankton Medical offers Medical care (behavioral health, geriatric, chronic care management, DOT physicals, physical exams, family medicine, maternal health, family planning, sexually-transmitted disease testing, nursing, health education, immunizations, preventative services, well child exams, acute care, immunizations, lab/x-ray, and women's health). Also offers Certified Application Counselors for the Health Insurance Marketplace. Horizon Health - Yankton Dental offers dental care services include cleanings, dental exams, bridges, crowns, dentures, digital x-rays, emergencies, extractions, fillings, mouth guards, partials, root canals, sealants and spacers.

Services for the clinic include family medicine, family planning, geriatric medicine, pediatrics, lab services, podiatry, pediatrics, preventative medicine, physical exams for women and children, and X-ray services.

A full service hospital providing hospital services, 24-hour emergency care, laboratory services, radiology services, cardiac rehab, physical, occupational and speech therapy services, wellness services, and wound care.

Provides quality home health care to residents of the Sioux Empire, Vermillion, and Chamberlain communities. Services offered include care for heart conditions, complex wound care, diabetes education and assessment, disease and symptom management, education on a newly diagnosed medical condition, home health aide, home infusion therapy education, home safety education, medication education, occupational therapy, pain management, pediatric care, physical therapy, postsurgical care, skilled nursing, speech therapy, and rehabilitation therapy while recovering from an orthopedic condition or hospital stay. They are most appropriate for individuals recently discharged from the hospital and are not fully recovered such as after surgery or new diagnosis, individuals recently diagnosed with an illness and needing education, and individuals who have a chronic condition that needs frequent clinical assessment such as diabetes, kidney, stroke, heart or lung disease.

Huron Clinic is a Family Medicine clinic, providing medical services to patients in Huron and the surrounding area. Services include Vaccinations and flu shots: adult and childhood immunizations, Family medicine, Routine physicals: annual, school, pre-employment, work, and DOT certified exams, Allergy and immunization: therapeutic injections, and allergy shot administration, Women's health: pap tests, breast screening, contraception, and STI/STD testing, Screening: in-house laboratory testing, bone density, cancer, diabetes, cholesterol, drug, alcohol, vision, and hearing. Cardio health: EKG and blood pressure screening, Pulmonary health: nebulizer treatments, pulmonary function testing, Diabetes: screening, education, diet information, weight management, and medication management, Minor surgery: mole/lesion removal, laceration repair, skin tag removal, wart removal, and liquid nitrogen treatment, Joint injections and aspirations: cortisone injections and fluid removal, Skin Cancer Screening, and Imaging: x-rays, ultrasound, and bone density testing.

Featured health services include Avera QuickLabs, emergency and trauma, pharmacy, therapy and rehabilitation, pregnancy and birth, radiology and imaging, respiratory and pulmonary care, sleep medicine, telemedicine, urgent care, urology, wellness and preventive care, women's health, and wound care.

Provides Medication-Assisted Treatment (Suboxone, Naloxone, Vivitrol) addressing opioid, alcohol, heroin, and methamphetamine addictions. Physically located in Rapid City, SD, but providing services anywhere in South Dakota via Telemedicine. ​​Medication assisted treatment is the use of FDA-approved medications in combination with counseling and other therapies to provide a whole-patient approach to treatment for substance use disorders (SUD). Other services include MAT services, HIV/HCV screenings, lab work, pregnancy tests, specialty and primary care referrals; Medication assistance programs, and Patient advocacy & resource connection. Frequently Asked Questions: Do I need to be clean? NO Do I need insurance? NO Do I need a referral? NO Can I just walk in? YES Is there help to pay for meds? YES Is perfection expected? NO

Horizon Health - Isabel is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Horizon Health - Isabel is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

Services include skilled nursing, physical therapy, occupational therapy, speech therapy, personal care, dressing, medication assistance, lab draws, and home infusion therapy. Also specializes in providing home care after surgery.

Services include Walk-in Urgent Visits (for both medical and dental), Schedule and same day appointments, Family Practice and Internal Medicine Primary Care for adults, Dental Care for all ages (including teeth cleanings), Sexual and Reproductive Health Services, On-site lab and X-Rays, On-Site Pharmacy, and After-Hours On-Call Provider 365 days a year. Primary and Pediatric Medical Clinic: Most routine medical services and several specialized fields including: physicals, immunizations, preventative medicine, chronic disease management, and counseling. Well child checkups, vaccinations, general pediatric health care. Mental Health: Offers outpatient counseling and psychiatric services, to both children and adults. Case management is offered to adults and families. Dental Clinic: Provides emergency, preventive, and oral health care. Accepts Medicaid, Private Insurance, Medicare, free of charge for the homeless and on a sliding fee scale for uninsured. One Heart Clinic: Providing primary family care to patients with a focus on patients with a primary language of Spanish. Pharmacy: Convenient, on-site location, CHCBH patients are able to fill most of their medications the same day as appointment.

Avera Medical Group Brookings is a multi-specialty medical group providing clinic laboratory, digital mammography, imaging and x-ray, 3D mammography, ear, nose and throat, family practice, general surgery, infusion/chemotherapy, internal medicine, obstetrics & gynecology, orthopedics, outreach specialists, pediatrics, physical therapy, dermatology, podiatry, and urology. A Coordinated Care Team is available to help identify resource support for community and primary healthcare needs; facilitation and connection to long-term counseling services to meet mental health needs, and clinic based counseling for interim or short-term support needs.

Providing family medicine (including flu shots).

Horizon Health - Eagle Butte is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

A full service hospital and family medicine clinic located in the community of Chamberlain, SD. The facility provides acute, emergency, and medical care.

Provides clinic services such as primary care, women's health, men's health, physicals, preventative medicine, pediatric care, enhanced laboratory services, immunizations, and health education.