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Specialty care include: Audiology, Home Based Primary Care, Lab, Mental Health, Pharmacy clinical services, Physical Therapy, Primary Care, Social Work, and Nutrition. The following programs and specialty care are available by telehealth: Cardiology, Occupational Therapy, Chronic Health Management, Oncology, Dermatology, Orthopedics, Diabetes Management, Pain Management, Endocrinology, Pharmacy Services, Gastroenterology, Prosthetics/Orthotics, Genomic Medicine, Psychiatry, Infectious Disease, Pulmonary, Mental Health, Surgery (pre-op), Nephrology, Low Vision, Neurology, Urology, and Wound Care.​

Providing a range of generalized and specialized services including a Sleep Center, Surgical Services, Pain Management, and Sports Medicine.

A full-service medical clinic with lab x-ray services onsite as well as wellness exams, vaccinations, and procedures.

Provides a full range of primary healthcare services including physical exams, chronic disease management, acute illness management, physicals, well child exams, children/adolescent/men/women healthcare services, immunizations, telemedicine related to medical and mental health needs, certified laboratory services, All Women Count services, assistance with Marketplace insurance enrollment, and allergy injections. Some sites provide Department of Transportation physicals. Nurse triage available for after-hours calls. Situation will be assessed by a registered nurse with further guidance provided. Strives to meet the needs of all patients, including the underinsured and underserved and offers services at a reduced rate to those who qualify.

Featured health services include cancer care, brain and spine care, children's health, dermatology, ear, nose, and throat, laboratory, orthopedics, therapy and rehabilitation, podiatry, pregnancy and birth, primary care, radiology and imaging, urgent care, urology, women's health, and cardiology.

Black Hills Urgent Care offers injury and illness care, immunizations and vaccinations, basic physicals and physicals for school, sports, and employment, and occupational medicine. COVID-19 tests are available.

A primary care and family medicine clinic.

Horizon Health - Isabel is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Horizon Health - Isabel is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

Sanford Health Mitchell offers the following specialties: 3D mammography, colonoscopy, family medicine, health coaching, immunizations, internal medicine, laboratory, MRI, nephrology, neurosurgery, OB/GYN, orthopedics, pediatric cardiology, physical medicine & rehabilitation, pulmonology, ultrasound, vascular care, vascular surgery, walk-in and x-ray.

Providing clinical health services for all ages, including Medications for Opioid Use Disorder, senior care, maternity, pediatric, men's health, LGBTQ+ care, vaccinations, lab services, and telehealth visits. A Community Health Worker is also available to help coordinate services.

A full service hospital providing hospital services, 24-hour emergency care, laboratory services, radiology services, cardiac rehab, physical, occupational and speech therapy services, wellness services, and wound care.

Provides a full range of primary healthcare services including physical exams, chronic disease management, acute illness management, physicals, well child exams, children/adolescent/men/women healthcare services, immunizations, telemedicine related to medical and mental health needs, certified laboratory services, All Women Count services, assistance with Marketplace insurance enrollment, and allergy injections. Some sites provide Department of Transportation physicals. Nurse triage available for after-hours calls. Situation will be assessed by a registered nurse with further guidance provided. Strives to meet the needs of all patients, including the underinsured and underserved and offers services at a reduced rate to those who qualify.

Provides a full range of primary healthcare services including physical exams, chronic disease management, acute illness management, physicals, well child exams, children/adolescent/men/women healthcare services, immunizations, telemedicine related to medical and mental health needs, certified laboratory services, All Women Count services, assistance with Marketplace insurance enrollment, and allergy injections. Some sites provide Department of Transportation physicals. Nurse triage available for after-hours calls. Situation will be assessed by a registered nurse with further guidance provided. Strives to meet the needs of all patients, including the underinsured and underserved and offers services at a reduced rate to those who qualify.

A full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Bison Clinic is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

Located on the Pine Ridge Reservation, it is an ambulatory care center with outpatient services. Services include primary care, pediatric, women's health, optometry, dental, behavioral health, podiatry, radiology, and laboratory tests.

Horizon Health - Yankton Medical offers Medical care (behavioral health, geriatric, chronic care management, DOT physicals, physical exams, family medicine, maternal health, family planning, sexually-transmitted disease testing, nursing, health education, immunizations, preventative services, well child exams, acute care, immunizations, lab/x-ray, and women's health). Also offers Certified Application Counselors for the Health Insurance Marketplace. Horizon Health - Yankton Dental offers dental care services include cleanings, dental exams, bridges, crowns, dentures, digital x-rays, emergencies, extractions, fillings, mouth guards, partials, root canals, sealants and spacers.

Services for the clinic include family medicine, family planning, geriatric medicine, pediatrics, lab services, podiatry, pediatrics, preventative medicine, physical exams for women and children, and X-ray services.

Featured health services include Avera QuickLabs, emergency and trauma, pharmacy, therapy and rehabilitation, pregnancy and birth, prenatal care, OB/GYN, radiology and imaging, respiratory and pulmonary care, sleep medicine, telemedicine, urgent care, urology, wellness and preventive care, women's health, and wound care.

Medical services provided include: adult medicine, women's health, obstetrics, pediatric medicine, physicals, wound care, minor surgeries, radiology, laboratory, disease management, rehabilitation and therapy services, and cardiology, podiatry, orthopedics, surgery outreach services.

Services include emergency room, ambulance, cardiac rehabilitation, chronic care management, gastroscopy, intensive/coronary care unit, mammograms, pulmonary rehab, physical, speech, and occupational therapies, and a sleep lab. Provides monthly services for blood pressure/blood sugars, walk-in immunizations, and foot care clinic. Also includes outreach clinics/telemedicine services for a variety of health needs.

Provides primary care, Patient Centered Medical Home (PCMH) outpatient services, and Pharmacy.

A full-service medical clinic with lab x-ray services onsite as well as wellness exams, vaccinations, and procedures.

Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), Nutrition Services, and Women's Health. The take-back site is available.

Horizon Health - Eagle Butte is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, prenatal care, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Provides clinic services such as primary care, women's health, men's health, physicals, preventative medicine, pediatric care, enhanced laboratory services, immunizations, and health education.