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Specialty care include: Audiology, Home Based Primary Care, Lab, Mental Health, Pharmacy clinical services, Physical Therapy, Primary Care, Social Work, and Nutrition. The following programs and specialty care are available by telehealth: Cardiology, Occupational Therapy, Chronic Health Management, Oncology, Dermatology, Orthopedics, Diabetes Management, Pain Management, Endocrinology, Pharmacy Services, Gastroenterology, Prosthetics/Orthotics, Genomic Medicine, Psychiatry, Infectious Disease, Pulmonary, Mental Health, Surgery (pre-op), Nephrology, Low Vision, Neurology, Urology, and Wound Care.​

A full-service medical clinic with lab x-ray services onsite as well as wellness exams, vaccinations, and procedures.

Offering multi-specialty health care services such as 3D mammography, family medicine, lab, x-ray, and ultrasound services, obstetrics and gynecology (OBGYN), pediatrics, prenatal care, physical therapy, sexual health and intimacy care, and women's health services. Also offers behavioral health services such as dialectical behavioral therapy (DBT) and eye movement desensitization and reprocessing (EMDR) therapy.

A full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Horizon Health - Eagle Butte is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, prenatal care, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), Nutrition Services, and Women's Health. The take-back site is available.

An outpatient clinic providing primary care, laboratory and pathology testing, mental health care, and suicide prevention.

Horizon Health - Huron is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, prenatal care, patient education, care management, DOT exams, immigration physicals, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Horizon Health - Huron also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Spanish and Karen translators available on-site.

Avera Medical Group Brookings is a multi-specialty medical group providing clinic laboratory, digital mammography, imaging and x-ray, 3D mammography, ear, nose and throat, family practice, general surgery, infusion/chemotherapy, internal medicine, obstetrics & gynecology, orthopedics, outreach specialists, pediatrics, physical therapy, dermatology, podiatry, and urology. A Coordinated Care Team is available to help identify resource support for community and primary healthcare needs; facilitation and connection to long-term counseling services to meet mental health needs, and clinic based counseling for interim or short-term support needs.

Horizon Health - Faith is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Horizon Health - Faith is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

Featured health services include Avera QuickLabs, emergency and trauma, pharmacy, therapy and rehabilitation, pregnancy and birth, prenatal care, OB/GYN, radiology and imaging, respiratory and pulmonary care, sleep medicine, telemedicine, urgent care, urology, wellness and preventive care, women's health, and wound care.

A family practice and women's health clinic offering comprehensive care to newborns, pediatrics, adult, and geriatric patients. Services include preventative care, annual examinations, Department of Transportation (DOT) examinations, immunizations, obstetrical care, women's health care, mental/behavioral health services, radiology, and lab services.

Providing the following medical services: Adult Medicine - annual checkups, wellness consultations, comprehensive evaluations, preventative care, and diagnostic services. Women's Health - annual health exams, pap smears, breast health services, and routine gynecological care. Obstetrics - prenatal and postpartum care in partnership with OB/GYN specialists. Pediatric Medicine - well-child visits, immunizations Minor Surgery - laceration repair, foreign body removal, wart removal, biopsies (skin or superficial lesions), excision of ingrown toenails, fractures and sprain care. Radiology - digital x-rays, CT whole body scans, MRI's, ultrasounds, DXA (Bone Density & Total Body Composition), Digital 3D Mammography, nuclear medicine, EKG's. Disease Management - can help monitor conditions such as hypertension, thyroid disease, diabetes, cardiac conditions, etc. Rehabilitation/Therapy Services - physical therapy, occupational therapy, speech therapy. Specialty Outreach Services - cardiology, podiatry, orthopedics, surgery.

Featured health services include emergency and trauma, laboratory, nutrition, pharmacy, therapy and rehabilitation, radiology and imaging, respiratory and pulmonary care, wellness and prevention care, and women's health.

Clinic services offered include Preventative Care, Pediatrics, Pregnancy Care, Women's Health, 3D Mammograms, Lab Work, and Imaging.

Featured health services include cancer care, brain and spine care, children's health, dermatology, ear, nose, and throat, laboratory, orthopedics, therapy and rehabilitation, podiatry, pregnancy and birth, primary care, radiology and imaging, urgent care, urology, women's health, and cardiology.

Offers a complete health care facility providing in-patient and emergency care, lab and medical imaging, visiting specialists, physical, occupational, and speech therapy.

Horizon Health - White River is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

A 25-bed critical access hospital that also houses an 84-bed senior care facility and specialty clinic for visiting physicians. The hospital offers 24-hour emergency service, inpatient and outpatient care, and hospice.

Provides quality home health care to residents of the Sioux Empire, Vermillion, and Chamberlain communities. Services offered include care for heart conditions, complex wound care, diabetes education and assessment, disease and symptom management, education on a newly diagnosed medical condition, home health aide, home infusion therapy education, home safety education, medication education, occupational therapy, pain management, pediatric care, physical therapy, postsurgical care, skilled nursing, speech therapy, and rehabilitation therapy while recovering from an orthopedic condition or hospital stay. They are most appropriate for individuals recently discharged from the hospital and are not fully recovered such as after surgery or new diagnosis, individuals recently diagnosed with an illness and needing education, and individuals who have a chronic condition that needs frequent clinical assessment such as diabetes, kidney, stroke, heart or lung disease.

Services include - 24-hour physician-covered emergency department, Diabetes education, Full-service laboratory, Medical imaging services, Digital mammography, Physical therapy, Occupational therapy, Speech therapy, Radiology, and Medication disposal.

A full-service medical clinic with lab x-ray services onsite as well as wellness exams, vaccinations, and procedures.

Offers primary care, mental health care, treatment for post traumatic stress disorder (PTSD), and suicide prevention. Also offers transitional and supportive housing for veterans experiencing homelessness. Gun safety locks are available through the Suicide Prevention Coordinator.

A family practice and women's health clinic offering comprehensive care to newborns, pediatric patients, adult and geriatric patients, preventative care, annual examinations, Department of Transportation (DOT) examinations, immunizations, obstetrical care, women's health care, mental/behavioral health services, and lab services.

A Family Medicine clinic, providing medical services to patients in Huron and the surrounding area. Services include: vaccinations and flu shots, adult and childhood immunizations, family medicine; routine physicals: annual, school, pre-employment, work, and DOT certified exams; allergy and immunization: therapeutic injections, and allergy shot administration; women's health: pap tests, breast screening, contraception, and STI/STD testing; screening: in-house laboratory testing, bone density, cancer, diabetes, cholesterol, drug, alcohol, vision, and hearing; cardio health: EKG and blood pressure screening; pulmonary health: nebulizer treatments, pulmonary function testing; diabetes: screening, education, diet information, weight management, and medication management; minor surgery: mole/lesion removal, laceration repair, skin tag removal, wart removal, and liquid nitrogen treatment, joint injections and aspirations, cortisone injections and fluid removal, skin cancer screening, and imaging: x-rays, ultrasound, and bone density testing.