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18-bed critical access hospital provides 24-hour emergency service, inpatient and outpatient care, ambulance service, home health care, laboratory services, physical therapy, and medication disposal.

Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), Nutrition Services, and Women's Health. The take-back site is available.

Medical services provided include: adult medicine, women's health, obstetrics, pediatric medicine, physicals, wound care, minor surgeries, radiology, laboratory, disease management, rehabilitation and therapy services, and cardiology, podiatry, orthopedics, surgery outreach services.

Horizon Health - Faith is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Horizon Health - Faith is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

Services for the clinic include family medicine, family planning, geriatric medicine, pediatrics, lab services, podiatry, pediatrics, preventative medicine, physical exams for women and children, and X-ray services.

Providing local medical care, assessments, treatments and referrals.

Services include skilled nursing, physical therapy, occupational therapy, speech therapy, personal care, dressing, medication assistance, lab draws, and home infusion therapy. Also specializes in providing home care after surgery.

Featuring personalized primary care, laboratory tests offering blood drawing services, prescriptions are processed through the mail or My HealtheVet, Intensive Outpatient Program (IOP) for Substance Abuse Disorder and outpatient addictive disorder services.

Providing family medicine (including flu shots).

A family practice and women's health clinic offering comprehensive care to newborns, pediatrics, adult, and geriatric patients. Services include preventative care, annual examinations, Department of Transportation (DOT) examinations, immunizations, obstetrical care, women's health care, mental/behavioral health services, radiology, and lab services.

Provides a full range of primary healthcare services including physical exams, chronic disease management, acute illness management, physicals, well child exams, children/adolescent/men/women healthcare services, immunizations, telemedicine related to medical and mental health needs, certified laboratory services, All Women Count services, assistance with Marketplace insurance enrollment, and allergy injections. Some sites provide Department of Transportation physicals. Nurse triage available for after-hours calls. Situation will be assessed by a registered nurse with further guidance provided. Strives to meet the needs of all patients, including the underinsured and underserved and offers services at a reduced rate to those who qualify.

A primary care and family medicine clinic. Services include Family medicine, Primary Care, Internal Medicine, Medical Imaging, Laboratory Services and Urgent Care.

Horizon Health - Mission is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, prenatal care, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Featured health services include cancer care, brain and spine care, children's health, dermatology, ear, nose, and throat, laboratory, orthopedics, therapy and rehabilitation, podiatry, pregnancy and birth, primary care, radiology and imaging, urgent care, urology, women's health, and cardiology.

Horizon Health - White River is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Providing clinical health services for all ages, including Medications for Opioid Use Disorder, senior care, maternity, pediatric, men's health, LGBTQ+ care, vaccinations, lab services, and telehealth visits. A Community Health Worker is also available to help coordinate services.

Sanford Health Mitchell offers the following specialties: 3D mammography, colonoscopy, family medicine, health coaching, immunizations, internal medicine, laboratory, MRI, nephrology, neurosurgery, OB/GYN, orthopedics, pediatric cardiology, physical medicine & rehabilitation, pulmonology, ultrasound, vascular care, vascular surgery, walk-in and x-ray.

Sanford Health Pierre Clinic offers health care services for patients of all ages.

A primary care and family medicine clinic.

Black Hills Urgent Care offers injury and illness care, immunizations and vaccinations, basic physicals and physicals for school, sports, and employment, and occupational medicine. COVID-19 tests are available.

Avera Medical Group Brookings is a multi-specialty medical group providing clinic laboratory, digital mammography, imaging and x-ray, 3D mammography, ear, nose and throat, family practice, general surgery, infusion/chemotherapy, internal medicine, obstetrics & gynecology, orthopedics, outreach specialists, pediatrics, physical therapy, dermatology, podiatry, and urology. A Coordinated Care Team is available to help identify resource support for community and primary healthcare needs; facilitation and connection to long-term counseling services to meet mental health needs, and clinic based counseling for interim or short-term support needs.

A 25-bed critical access hospital that also houses an 84-bed senior care facility and specialty clinic for visiting physicians. The hospital offers 24-hour emergency service, inpatient and outpatient care, and hospice.

The Avera Winner Medical Clinic is a member of the Avera McKennan Primary Care Network and Avera Health. Services include laboratory, x-ray, and Beltone hearing aid specialist on-site monthly.

A Family Medicine clinic, providing medical services to patients in Huron and the surrounding area. Services include: vaccinations and flu shots, adult and childhood immunizations, family medicine; routine physicals: annual, school, pre-employment, work, and DOT certified exams; allergy and immunization: therapeutic injections, and allergy shot administration; women's health: pap tests, breast screening, contraception, and STI/STD testing; screening: in-house laboratory testing, bone density, cancer, diabetes, cholesterol, drug, alcohol, vision, and hearing; cardio health: EKG and blood pressure screening; pulmonary health: nebulizer treatments, pulmonary function testing; diabetes: screening, education, diet information, weight management, and medication management; minor surgery: mole/lesion removal, laceration repair, skin tag removal, wart removal, and liquid nitrogen treatment, joint injections and aspirations, cortisone injections and fluid removal, skin cancer screening, and imaging: x-rays, ultrasound, and bone density testing.

A full-service medical clinic with lab x-ray services onsite as well as wellness exams, vaccinations, and procedures.