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Services include cancer services/oncology, cardiology, chaplain services, diabetes care, diagnostic imaging, emergency and trauma care, home health and hospice, home medical equipment, occupational health, orthopedics, pediatrics, rehabilitation services, senior services, sports medicine, telemedicine, wellness services, women's specialty services, and family medicine.

Featured health services include cancer care, blood diseases and disorders, brain and spine care, dentistry, emergency and trauma, heart and vascular care, infectious disease and public health, laboratory, nutrition, pain management, pregnancy and birth, Radiology and imaging, respiratory and pulmonary care, sleep medicine, surgery, telemedicine, therapy and rehabilitation, wellness and preventive care, women's health, and wound care.

Avera Medical Group McGreevy clinic locations offer family care to Sioux Falls and the surrounding area. Provides a variety of services including regular check-ups or vaccines, plus care for injuries and illnesses.

Horizon Health - Fort Thompson is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Walk-in appointments welcome.

Providing family medicine (including flu shots).

Featured health services include cancer care, brain and spine care, children's health, dermatology, ear, nose, and throat, laboratory, orthopedics, therapy and rehabilitation, podiatry, pregnancy and birth, primary care, radiology and imaging, urgent care, urology, women's health, and cardiology.

Horizon Health - Yankton Medical offers Medical care (behavioral health, geriatric, chronic care management, DOT physicals, physical exams, family medicine, maternal health, family planning, sexually-transmitted disease testing, nursing, health education, immunizations, preventative services, well child exams, acute care, immunizations, lab/x-ray, and women's health). Also offers Certified Application Counselors for the Health Insurance Marketplace. Horizon Health - Yankton Dental offers dental care services include cleanings, dental exams, bridges, crowns, dentures, digital x-rays, emergencies, extractions, fillings, mouth guards, partials, root canals, sealants and spacers.

Offers the following services to males and females in their reproductive years on a sliding scale - male/female reproductive health exams, birth control services, sexually transmitted infection testing, treatment and education, pregnancy testing, and educational programs to community groups and schools on request, regarding sexually transmitted infections and birth control methods. *Due to Title X funding, parental consent is not required for those under 18.

Services for the clinic include family medicine, family planning, geriatric medicine, pediatrics, lab services, podiatry, pediatrics, preventative medicine, physical exams for women and children, and X-ray services.

A full service hospital providing hospital services, 24-hour emergency care, laboratory services, radiology services, cardiac rehab, physical, occupational and speech therapy services, wellness services, and wound care.

Offers a wide range of services in general medicine, family medicine, geriatrics, minor surgical procedures, and routine annual exams. Services include physicals and annual exams, pre-employment physicals, wellness exams, athletic physicals, access to various specialists, biopsies and minor surgical procedures, urine drug testing, immunizations, patient education, preventive healthcare, and routine pre-natal and obstetrics care.

Rural Health Clinic provides primary care including family medicine and ancillary services. Board Certified Physicians and Nurse Practitioners tailor health care services to each individual's needs. Services include family medicine, family wellness exams, fracture care, geriatric care, minor surgical procedures, pediatric care, prenatal/gynecology, and vaccinations.

Huron Clinic is a Family Medicine clinic, providing medical services to patients in Huron and the surrounding area. Services include Vaccinations and flu shots: adult and childhood immunizations, Family medicine, Routine physicals: annual, school, pre-employment, work, and DOT certified exams, Allergy and immunization: therapeutic injections, and allergy shot administration, Women's health: pap tests, breast screening, contraception, and STI/STD testing, Screening: in-house laboratory testing, bone density, cancer, diabetes, cholesterol, drug, alcohol, vision, and hearing. Cardio health: EKG and blood pressure screening, Pulmonary health: nebulizer treatments, pulmonary function testing, Diabetes: screening, education, diet information, weight management, and medication management, Minor surgery: mole/lesion removal, laceration repair, skin tag removal, wart removal, and liquid nitrogen treatment, Joint injections and aspirations: cortisone injections and fluid removal, Skin Cancer Screening, and Imaging: x-rays, ultrasound, and bone density testing.

Specialty care include: Audiology, Home Based Primary Care, Lab, Mental Health, Pharmacy clinical services, Physical Therapy, Primary Care, Social Work, and Nutrition. The following programs and specialty care are available by telehealth: Cardiology, Occupational Therapy, Chronic Health Management, Oncology, Dermatology, Orthopedics, Diabetes Management, Pain Management, Endocrinology, Pharmacy Services, Gastroenterology, Prosthetics/Orthotics, Genomic Medicine, Psychiatry, Infectious Disease, Pulmonary, Mental Health, Surgery (pre-op), Nephrology, Low Vision, Neurology, Urology, and Wound Care.​

Horizon Health - Isabel is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Horizon Health - Isabel is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

Services include behavioral health (including Substance Use Prevention), Community Health Representatives, dental care, diabetes care, health promotion/disease prevention, immunizations, laboratory, nursing, medical imaging, optometry, pharmacy (Prescription Assistance if eligible), Primary Care, public health nursing, smoking cessation, specialty clinics (e.g. OB/GYN, Mammography, Telehealth), weight loss/nutrition, well child care, women's health, and Wowasake Wellness Center

Services include Walk-in Urgent Visits (for both medical and dental), Schedule and same day appointments, Family Practice and Internal Medicine Primary Care for adults, Dental Care for all ages (including teeth cleanings), Sexual and Reproductive Health Services, On-site lab and X-Rays, On-Site Pharmacy, and After-Hours On-Call Provider 365 days a year. Primary and Pediatric Medical Clinic: Most routine medical services and several specialized fields including: physicals, immunizations, preventative medicine, chronic disease management, and counseling. Well child checkups, vaccinations, general pediatric health care. Mental Health: Offers outpatient counseling and psychiatric services, to both children and adults. Case management is offered to adults and families. Dental Clinic: Provides emergency, preventive, and oral health care. Accepts Medicaid, Private Insurance, Medicare, free of charge for the homeless and on a sliding fee scale for uninsured. One Heart Clinic: Providing primary family care to patients with a focus on patients with a primary language of Spanish. Pharmacy: Convenient, on-site location, CHCBH patients are able to fill most of their medications the same day as appointment.

Avera Medical Group Brookings is a multi-specialty medical group providing clinic laboratory, digital mammography, imaging and x-ray, 3D mammography, ear, nose and throat, family practice, general surgery, infusion/chemotherapy, internal medicine, obstetrics & gynecology, orthopedics, outreach specialists, pediatrics, physical therapy, dermatology, podiatry, and urology. A Coordinated Care Team is available to help identify resource support for community and primary healthcare needs; facilitation and connection to long-term counseling services to meet mental health needs, and clinic based counseling for interim or short-term support needs.

Providing family medicine (including flu shots).

Horizon Health - Eagle Butte is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Sanford Vermillion Medical Center is a full service hospital and clinic providing the following services: 24-Hour Emergency Care, Ground and Air Ambulance support/access, medical, surgical, pediatric, and obstetrical care, outpatient nursing services (including chemotherapy), family medicine clinic, diagnostic services, home care and hospice programs, outpatient mental health counseling, rehabilitation therapies, respiratory care, acute care hours Saturday morning, Sunday afternoon, and weekday evenings, sports medicine, community health education, specialty outreach services (cardiology, diagnostic radiology, ENT surgery, general surgery, neurology, nephrology, oncology, orthopedics, podiatry, psychiatry, pulmonology, urology, and vascular surgery), and University of South Dakota student health services. Vermillion Medical Center has a teaching affiliation with USD Health Science Program.

Provides clinic services such as primary care, women's health, men's health, physicals, preventative medicine, pediatric care, enhanced laboratory services, immunizations, and health education.

Horizon Health - Mission is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

An outpatient clinic providing primary care, laboratory and pathology testing, mental health care, and suicide prevention.

Black Hills Urgent Care offers injury and illness care, immunizations and vaccinations, basic physicals and physicals for school, sports, and employment, and occupational medicine. COVID-19 tests are available.