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Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), Nutrition Services, and Women's Health. The take-back site is available.

A full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Bison Clinic is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

Medical services include: Family medicine Obstetrics and gynecology Pediatrics Acute care Orthopedics and sports medicine 3D mammography Cardiology - adult and pediatric Certified nurse midwife Ear, nose and throat Pulmonology Vascular surgery Weight loss management Behavioral health counseling provides brief therapy for individuals, including mental health assessment, crisis intervention and referrals for children, couples and families. Psycho-social support for individual with chronic or newly diagnosed health conditions and wellness support.

Horizon Health - Mission is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, prenatal care, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Offering multi-specialty health care services such as 3D mammography, family medicine, lab, x-ray, and ultrasound services, obstetrics and gynecology (OBGYN), pediatrics, prenatal care, physical therapy, sexual health and intimacy care, and women's health services. Also offers behavioral health services such as dialectical behavioral therapy (DBT) and eye movement desensitization and reprocessing (EMDR) therapy.

Horizon Health - De Smet Medical is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

A primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs. Services include Family medicine, Bone density screening, BOTOX® cosmetic rejuvenation, Concussion management, Glycolic facial peels, Laboratory, Occupational therapy, Office-based surgery, Physical therapy, Speech therapy, and X-ray.

Offers a complete health care facility providing in-patient and emergency care, lab and medical imaging, visiting specialists, physical, occupational, and speech therapy.

A full service hospital and family medicine clinic located in the community of Chamberlain, SD. The facility provides acute, emergency, and medical care.

A family practice and women's health clinic offering comprehensive care to newborns, pediatric patients, adult and geriatric patients, preventative care, annual examinations, Department of Transportation (DOT) examinations, immunizations, obstetrical care, women's health care, mental/behavioral health services, and lab services.

Medical services provided include: Adult Medicine - annual checkups, wellness consultations, comprehensive evaluations, preventative care, and diagnostic services. Women's Health - annual health exams, pap smears, breast health services, and routine gynecological care. Obstetrics - prenatal and postpartum care in partnership with OB/GYN specialists. Minor Surgery - laceration repair, foreign body removal, wart removal, biopsies (skin or superficial lesions), excision of ingrown toenails, fractures and sprain care. X-Rays/Laboratory Services - some of the testing is done on site. Tests that cannot be performed on site are provided at Pioneer Memorial Hospital in Viborg. Referrals - connects patients with a specialist in any area Disease Management - monitor conditions such as hypertension, thyroid disease, diabetes, cardiac conditions, etc. Therapy services including speech, physical, and occupational

A full service hospital and family medicine clinic located in the community of Aberdeen, SD. The facility provides acute, emergency, and medical care, full lab, with diagnostic testing, outpatient infusion, respiratory therapy, radiology, rehabilitation, diabetes care, pharmacy, flu shots, surgery, women's center/labor and delivery, oncology/cancer, and cardiology/heart.

Clinic locations offer family care to Sioux Falls and the surrounding area. Provides a variety of services for family and primary care (including flu shots) as well as prenatal care and OB/GYN. Other health services include yearly checkups, treatment of minor illnesses, and management of chronic conditions.

A family practice and women's health clinic offering comprehensive care to newborns, pediatrics, adult, and geriatric patients. Services include preventative care, annual examinations, Department of Transportation (DOT) examinations, immunizations, obstetrical care, women's health care, mental/behavioral health services, radiology, and lab services.

Medical services provided include: adult medicine, women's health, obstetrics, pediatric medicine, physicals, wound care, minor surgeries, radiology, laboratory, disease management, rehabilitation and therapy services, and cardiology, podiatry, orthopedics, surgery outreach services.

Medical services that are offered include allergy, asthma, and immunology, dermatology, ear, nose, and throat, family medicine, gastroenterology, general surgery, internal medicine, interventional pain, ophthalmology, optometry, pediatrics, podiatry, and rheumatology.

Wall Monument Medical Clinic is a primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs of you and your family. Services include Family medicine, Electrocardiogram, Laboratory, and Medical imaging.

Medical services that are offered include allergy, asthma, and immunology, dermatology, ear, nose, and throat, family medicine, gastroenterology, general surgery, internal medicine, interventional pain, ophthalmology, optometry, pediatrics, podiatry, and rheumatology.

Sanford Health Pierre Clinic offers health care services for patients of all ages.

Provides primary care, Patient Centered Medical Home (PCMH) outpatient services, and Pharmacy.

Clinic locations offer family care to Sioux Falls and the surrounding area. Provides a variety of services for family and primary care (including flu shots) as well as prenatal care and OB/GYN. Other health services include yearly checkups, treatment of minor illnesses, and management of chronic conditions.

Spearfish Monument Medical Clinic is a primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs of you and your family. Services include audiology, ear, nose, & throat, general surgery, obstetrics & gynecology (OB/GYN), pediatrics, prenatal care, radiology, concussion management, hearing aids, laboratory, medical imaging, and ultrasound.

Custer Clinic is a primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs of you and your family. Services include Digital mammography, Family medicine, Fracture care, Geriatric care, Minor surgical procedures, Pediatrics, including childhood immunizations, Prenatal/gynecology, Pulmonary function testing, Vaccinations, including flu vaccines, Vasectomy, and Wellness exams.

Located on the Pine Ridge Reservation, it is an ambulatory care center with outpatient services. Services include primary care, pediatric, women's health, optometry, dental, behavioral health, podiatry, radiology, and laboratory tests.

Medical services that are offered include allergy, asthma, and immunology, dermatology, ear, nose, and throat, family medicine, gastroenterology, general surgery, internal medicine, interventional pain, ophthalmology, optometry, pediatrics, podiatry, and rheumatology.