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Sanford Vermillion Medical Center is a full service hospital and clinic providing the following services: 24-Hour Emergency Care, Ground and Air Ambulance support/access, medical, surgical, pediatric, and obstetrical care, outpatient nursing services (including chemotherapy), family medicine clinic, diagnostic services, home care and hospice programs, outpatient mental health counseling, rehabilitation therapies, respiratory care, acute care hours Saturday morning, Sunday afternoon, and weekday evenings, sports medicine, community health education, specialty outreach services (cardiology, diagnostic radiology, ENT surgery, general surgery, neurology, nephrology, oncology, orthopedics, podiatry, psychiatry, pulmonology, urology, and vascular surgery), and University of South Dakota student health services. Vermillion Medical Center has a teaching affiliation with USD Health Science Program.

Horizon Health - Aberdeen is full-service medical clinic offering the following services -preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Provides a variety of services including patient care, diagnostic services, support services, chemotherapy, emergency department, heart health, Planet Heart vascular and heart screening, nursing service, maternity care, medical/surgical, newborn nursery, pediatrics, respite care, swing bed, outpatient treatment, pain management, pregnancy and childbirth, rehabilitation services, cardiac rehab, occupational therapy, physical therapy, speech therapy, sleep study lab, surgical procedures, and telehealth.

Services provided include: ambulatory clinic, laboratory, X-Ray, pharmacy, dental unit, public health nursing, diabetes care, fitness program, mental health services, and optometry services. Specialty care clinics available: cardiology, wound care, OBGYN Prescription Assistance - Enrolled members of a Native American tribe can get free prescriptions by visiting their local IHS.

Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), Nutrition Services, and Women's Health. The take-back site is available.

COVID Testing Option: ​Oyate Health Center Urgent Care 3200 Canyon Lake Drive 7:00am - 7:00pm (MT), 7 days a week Christmas Eve closes at 3pm (MT). Closed on Thanksgiving Day, and Christmas Day and New Year's Day. Oyate Health Center provides primary medical care, outpatient clinic, and urgent care. Additional outpatient services that are provided on site include optometry, pharmacy (Prescription Drug Take Back Site, blue drop-box by pharmacy), laboratory, radiology, dental, physical therapy, podiatry, and social services. Oyate Health Center has 2 sweat lodges. Please call for details. Oyate Health Center provides direct health services to Native Americans and provides contract health care services and referrals to those that are eligible within IHS requirements. This means that if a patient is enrolled in a federally recognized tribe or can prove lineage of descent of an enrolled tribal member; the patient may receive direct care services at Oyate Health Center. Prescription Assistance - Any Native American enrolled in a federally recognized tribe can receive prescription expense assistance at any IHS facility.

A full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Horizon Health - Fort Thompson is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Walk-in appointments welcome.

Medical services that are offered include allergy, asthma, and immunology, dermatology, ear, nose, and throat, family medicine, gastroenterology, general surgery, internal medicine, interventional pain, obstetrics and gynecology, ophthalmology, optometry, pediatrics, podiatry, prenatal care, and rheumatology.

A multi-specialty health care clinic with a variety of specialties such as: cardiology; family practice; pediatrics; radiology; urology; orthopedics; general surgery; internal medicine; OB/GYN; palliative medicine; geriatric medicine; full service laboratory; prenatal care; pulmonology; nephrology; rheumatology; physical medicine; and diagnostic imaging center.

A primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs. Services include Family medicine, Bone density screening, BOTOX® cosmetic rejuvenation, Concussion management, Glycolic facial peels, Laboratory, Occupational therapy, Office-based surgery, Physical therapy, Speech therapy, and X-ray.

Provides a variety of medical services ranging from infants to older adults. These include general medical care, preventative health care, newborn/pediatric/adolescent/adult/geriatric care, OB/GYN, prenatal care, laboratory services, radiology, school and sports physicals, hospice care, orthopedic care, behavioral health, CT, and sleep studies.

The multi-campus facilities of Avera McKennan Hospital and University Health Center include: a network of primary and specialty clinics, Avera Behavioral Health Center, Avera Heart Hospital of South Dakota, Avera Living Well Center, Avera Prince of Peace long-term care and retirement community. The hospital's main campus includes the Avera Cancer Institute, Plaza 1, Plaza 2, Plaza 3 and Plaza 4, Avera Medical Group 7th Avenue, Avera Surgery Center, and the Center for Family Medicine.

Clinic services offered include Preventative Care, Pediatrics, Pregnancy Care, Women's Health, 3D Mammograms, Lab Work, and Imaging.

Sanford Health Mitchell offers the following specialties: 3D mammography, colonoscopy, family medicine, health coaching, immunizations, internal medicine, laboratory, MRI, nephrology, neurosurgery, OB/GYN, orthopedics, pediatric cardiology, physical medicine & rehabilitation, pulmonology, ultrasound, vascular care, vascular surgery, walk-in and x-ray.

Providing general and specialized medical care and occupational services. Acute care services.

Spearfish Monument Medical Clinic is a primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs of you and your family. Services include audiology, ear, nose, & throat, general surgery, obstetrics & gynecology (OB/GYN), pediatrics, prenatal care, radiology, concussion management, hearing aids, laboratory, medical imaging, and ultrasound.

The Family Medicine Residency Clinic provides comprehensive care for the entire family in all phases of life, from childhood to senior years. Services include care for acute and chronic medical problems, care for expectant moms, well-baby visits and immunizations, school sports physicals, OB/GYN, prenatal care, annual check-ups, immunizations, and minor surgical procedures.

Clinic services offered include Preventative Care, Pediatrics, Pregnancy Care, Women's Health, 3D Mammograms, Lab Work, and Imaging.

A primary care, family medicine clinic that provides comprehensive care for the entire family through all phases of life, from childhood to senior years. Board certified physicians and physician assistants offer health care services sensitive to individual needs. Services include: outpatient counseling for adults and adolescents, family medicine, audiology/hearing aids, bone density screening, childhood & adult immunizations, general surgery, laboratory, OB/GYN, office-based surgery, sports & pre-employment physicals, and x-ray.

Clinic locations offer family care to Sioux Falls and the surrounding area. Provides a variety of services for family and primary care (including flu shots) as well as prenatal care and OB/GYN. Other health services include yearly checkups, treatment of minor illnesses, and management of chronic conditions.

A full service hospital providing hospital services, 24-hour emergency care, laboratory services, radiology services, cardiac rehab, physical, occupational and speech therapy services, wellness services, and wound care.

A primary care and family medicine clinic. Services include Family medicine, Primary Care, Internal Medicine, Medical Imaging, Laboratory Services and Urgent Care.

Falls Community Health is a family practice medical clinic and dental clinic with emphasis on health promotion and disease prevention. The Community Health Center was established in 1979 with its goal being to remove the barriers, primarily financial, that exist and limit the access of lower income individuals or families seeking primary health care services.  ​Services for the general public include family health, lab radiology, well-child care, immunizations, family planning (including birth control, STD screening and treatment), patient education, and dental care. Services for established clinic patients include outpatient mental health and substance abuse counseling, psychiatry services, transportation assistance (transporter of last resort), and pharmacy assistance to clients of the Falls Community Health Care Clinic.

Services available include hospital (inpatient, outpatient and observation), swing bed (skilled nursing services), dietitian and nutrition services, rehabilitation services, laboratory services, X-ray and CT services, MRI, mobile mammogram and Dexa scan, clinic services, emergency services 24/7/365, telemental health, and various outreach services.