Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, the Browns Valley Clinic in Browns Valley, Minnesota, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), and Women's Health. The take-back site is available.

Monument Health Spearfish Hospital offers extensive patient services centralized at one location which includes both the hospital and Spearfish Monument Medical Clinic. Services include emergency care: 24 hours a day / 7 days a week, diabetes care, heart & vascular care, home care, hospice, labor & delivery, laboratory services, medical imaging, physical therapy & rehabilitation, surgery, swing-bed program, telemedicine, and serves as a medication disposal site.

Horizon Health - Wessington Springs Medical is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Horizon Health - Wessington Springs Dental provides a full range of family oral health services including preventative care (check ups, fillings), restorative and cosmetic dentistry (crowns, bridges) , endodontics, and oral surgery (root canals, extractions).

Featured health services include cancer care, blood diseases and disorders, brain and spine care, dentistry, emergency and trauma, heart and vascular care, infectious disease and public health, laboratory, nutrition, pain management, pregnancy and birth, Radiology and imaging, respiratory and pulmonary care, sleep medicine, surgery, telemedicine, therapy and rehabilitation, wellness and preventive care, women's health, and wound care.

An independent, nonprofit critical access hospital providing the following services: emergency care, cardiac rehabilitation services, coronary care, diabetes counseling, intensive care, in-patient services, obstetrics/childbirth services, occupational therapy, physical therapy, pulmonary care services, radiology services, respiratory therapy, sleep studies, swing bed program, surgical services, and on-site specialty providers (orthopedics, pain management, cardiology, urology, and audiology).

Medical services that are offered include allergy, asthma, and immunology, dermatology, ear, nose, and throat, family medicine, gastroenterology, general surgery, internal medicine, interventional pain, obstetrics and gynecology, ophthalmology, optometry, pediatrics, podiatry, and rheumatology.

Offers over 30 specialties including: child abuse, pediatric genetics, cardiology, critical care, developmental, emergency medicine, endocrinology, gastroenterology, hospitalist, hematology and oncology, infectious disease, neonatology, nephrology, neurology, orthopedics, palliative care, psychiatry, psychology, pulmonology, radiology, rehabilitation, rheumatology, sleep medicine, surgery, and urology. Also provides CHILD services, genetic counseling, immunizations, diabetes education, nutrition, and travel medicine.

Offers the following: hospital care, surgical services, diagnostic services, therapy services, respiratory care, and intravenous therapy.

Providing general and specialized medical care and occupational services. Acute care services.

Sanford Webster Clinic is a community clinic for the whole family (Family Medicine), and has urgent health care hours as well.

A primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs. Services include Family medicine, Bone density screening, BOTOX® cosmetic rejuvenation, Concussion management, Glycolic facial peels, Laboratory, Occupational therapy, Office-based surgery, Physical therapy, Speech therapy, and X-ray.

Spearfish Monument Medical Clinic is a primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs of you and your family. Services include audiology, ear, nose, & throat, general surgery, obstetrics & gynecology (OB/GYN), pediatrics, radiology, concussion management, hearing aids, laboratory, medical imaging, and ultrasound.

Offers the following: hospital care, surgical services, diagnostic services, therapy services, respiratory care, and intravenous therapy.

Provides emergency care, pediatrics, family medicine, general practice medicine, inpatient and outpatient rehabilitation therapy, medical imaging, OBGYN, 3D mammography (Free mammogram and cancer screening program 'We've Got You Covered'), chemotherapy, laboratory services, internal medicine, general surgery, dialysis, home health, hospice, intensive care, outpatient treatment, same day surgery, and swing bed.

Offers same day surgical procedures in a convenient, personal setting. These include Pediatrics, Orthopedics, general surgery, and plastic surgery.

Sponsored by Avera, Avera St. Luke's facilities include a hospital and comprehensive retirement communities in Aberdeen and Eureka, and clinics. Services include: addiction care (residential and outpatient services), behavioral health services (inpatient and outpatient), cancer services/medical oncology and radiation oncology, cardiology, dermatology, diabetes care, diagnostic imaging, emergency and trauma care, home health and hospice, Human Performance Center, hyperbaric oxygen treatments (wounds only), kidney dialysis, long-term care, nephrology, OB/GYN, occupational health, orthopedics, pain management, pediatrics, physical medicine and rehab, podiatry, primary care (family practice and internal medicine), primary care clinic (Groton, SD, and Ellendale, ND), pulmonology, same-day sick visit clinic, sleep lab, spine surgery, surgery, after-hours clinic, urology, wellness services, women's specialty services, and wound care.

A primary care, family medicine clinic that provides comprehensive care for the entire family through all phases of life, from childhood to senior years. Board certified physicians and physician assistants offer health care services sensitive to individual needs. Services include: outpatient counseling for adults and adolescents, family medicine, audiology/hearing aids, bone density screening, childhood & adult immunizations, general surgery, laboratory, OB/GYN, office-based surgery, sports & pre-employment physicals, and x-ray.

Medical services that are offered include allergy, asthma, and immunology, dermatology, ear, nose, and throat, family medicine, gastroenterology, general surgery, internal medicine, interventional pain, obstetrics and gynecology, ophthalmology, optometry, pediatrics, podiatry, and rheumatology.

A multi-specialty health care clinic with a variety of specialties such as: cardiology; family practice; pediatrics; radiology; urology; orthopedics; general surgery; internal medicine; OB/GYN; palliative medicine; geriatric medicine; full service laboratory; pulmonology; nephrology; rheumatology; physical medicine; and diagnostic imaging center.

Brookings Hospital is a licensed 49-bed hospital. Services include same day surgery/operating room, emergency room, inpatient care, obstetrics, and ancillary services - radiology, rehab/therapy, and laboratory. Full service hospital that provides both inpatient and outpatient care.

Avera Medical Group Brookings is a multi-specialty medical group providing clinic laboratory, digital mammography, imaging and x-ray, 3D mammography, ear, nose and throat, family practice, general surgery, infusion/chemotherapy, internal medicine, obstetrics & gynecology, orthopedics, outreach specialists, pediatrics, physical therapy, dermatology, podiatry, and urology. A Coordinated Care Team is available to help identify resource support for community and primary healthcare needs; facilitation and connection to long-term counseling services to meet mental health needs, and clinic based counseling for interim or short-term support needs.

A full service hospital level one trauma with 24-hour emergency care. Offers acute care services including Cardiology, Oncology, Obstetrics, Orthopedics, sleep disorder center, inpatient and outpatient surgery, rehabilitative services, and comprehensive services for women and children.

Medical services that are offered include allergy, asthma, and immunology, dermatology, ear, nose, and throat, family medicine, gastroenterology, general surgery, internal medicine, interventional pain, obstetrics and gynecology, ophthalmology, optometry, pediatrics, podiatry, and rheumatology.

A full service hospital located in Webster, SD. The facility provides emergency medicine, pediatrics, surgery, mammography, adult trauma care, and colorectal screenings.

A multi-specialty health care clinic with a variety of specialties such as: cardiology; family practice; pediatrics; radiology; urology; orthopedics; general surgery; internal medicine; OB/GYN; palliative medicine; geriatric medicine; full service laboratory; pulmonology; nephrology; rheumatology; physical medicine; and diagnostic imaging center.