The Great Plains Regional office is responsible for the direction and oversight of Bureau responsibilities and activities in South Dakota, North Dakota, and Nebraska. The Office of the Regional Director provides program direction and supervision to 12 Agencies encompassing 16 federally recognized Tribes. Programs includes: tribal government, enrollment, claims, self-determination, housing improvement program, loan guaranty and interest subsidy program, land titles and records office, probate and estate services, real estate services, Indian land consolidation program, Division of Natural Resources, Human services (which includes general assistance, burial assistance, disaster assistance, emergency assistance, adult care assistance, and child assistance), Tribal transportation program, road maintenance, and Division of Environment, Safety, and Cultural Resources Managements.

Assists with rent assistance for eviction notices, utility assistance for disconnect notices, hotel stays (does not provide a homeless shelter), gasoline or bus pass for stranded motorists or for medical reasons, minor car repairs, assistance after a disaster (i.e. house fire, flood, etc.), and prescription assistance for qualifying medications. The needs of the individual/family will be assessed, and certain documentation may be required (ex. driver's license). After business hours, The Salvation Army of Brookings County works with the Brookings County Sheriff or City Police to help individuals and families in the case of an emergency/immediate need.

A national grant assistance program that provides financial assistance to eligible American Legion Auxiliary members who are impacted by a natural disaster or in a time of financial crisis. Disaster Assistance: Applicants must either received damage to their primary residence, been displaced/evacuated from their residence or experienced basic out-of-pocket emergency expenses. Hardship Assistance: Applicants have to have past due expenses related to their primary residence and/or basic household utilities. Grants are awarded for $3,000 per grantee and one grant (disaster or hardship) will be awarded in a 12-month period.